| | Category | CH | P01 | Analyze This: Aspirin Content in Powder Form and Tablets |
| | Abstract | Aspirin is an analgesic and anti-inflammatory agent that is widely used all |
| | over the world. There are different analytical methods that could be used |
| | to detect the content of Aspirin powder or its concentration in |
| | pharmaceutical preparations. In this experiment, three different methods of |
| | analysis were tested for accuracy and practicality. The three analytical |
| | procedures are the USP method of Acid-Base Titration, UV Spectroscopy, |
| | and Reverse Phase HPLC. The Acid-Base Titration showed accurate |
| | results but was somewhat cumbersome and tedious to use on consistent |
| | basis. UV Spectroscopy and Reverse Phase HPLC showed both accurate |
| | results and more practicality for everyday use. To test a more real-life |
| | example, three different commercially available preparations containing |
| | known amounts of Aspirin were tested for their concentration of the drug |
| | using UV Spectroscopy and Reverse Phase HPLC. Percent error and |
| | statistical analysis showed that the actual concentration of Aspirin in |
| | these preparations varied somewhat from the stated concentration |
| | depending on the brand. In conclusion, although all analytical methods |
| | seem to be accurate, UV Spectroscopy and HPLC are more practical for |
| | drug analysis and quality control, which is an important process to monitor |
| | different commercially available brands containing the drug. |
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| | |
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| | |
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| | |
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